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Preclinical Imaging

Molecular medicine – as a developing independent Subject – has come to be positively attracting professionals from places widely distinctive as cardiology, oncology, immunology, neurology, biology, chemistry, genetics, genomics, nuclear radiology medicine and pharmacology.

Imaging is usually performed by attaching a fluorescent tag Or tag to the molecule of interest, which can be detected by the emission of light when excited with specificity. Molecular imaging intends to show the source of disease carriers through the combined use of molecular bio-markers and probes, employing a huge variety of preclinical imaging methods. Molecular Imaging is the visualization of Molecules or molecular events using probes. It’s used to offer characterization and measurement of biological processes in living animals and humans (in vivo).

Molecular imaging is a research discipline of Non-invasive imaging technologies which may create images of functional and bodily facets of the body. MI is directed at testing and developing novel strategies specific molecular pathways in vivo, especially the ones that are targets in disease processes. Rather than other conventional imaging techniques (like Microscopy), this imaging technique creates images on tissues within a living organism. Molecular imaging primarily provides information about biological processes (function) while other imaging techniques like CT, X-rays, MRI and ultrasound, capture the phenotypic changes in the gross anatomic level that result from molecular processes.
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During the past few decades Magnetic Resonance Imaging (MRI) – especially, preclinical MRI – and Magnetic Resonance Spectroscopy (MRS), have proven themselves to be extremely helpful for research applications from the various Life Sciences. Research is heavily reliant on creature MRI that has, in many cases, become recognized as the benchmark for this area. Some of preclinical and clinical MRI’s applications include research regarding arthritis oncology and metabolic disorders; and respiratory studies. Recent developments in molecular biology and genome research have resulted in increased utilization of MRI applications in animals. Rapid phenotyping of transgenic animals and imaging are but two applications which have extended preclinical MRI’s role .
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Preclinical MRI applications’ range includes brain and Organ imaging, tumor assessment, disease imaging. Potential research programs include analysis of protein interactions investigation of agents and new contrast mechanisms, tracking gene expression, and determination of pharmacokinetics.

Although small animal scanners are superior to clinical Scanners concerning providing a far better signal-to-noise ratio, the available pulse sequences are not the same as those in clinical scanners, and the magnetic field strength is higher. Molecular imaging aims to reveal the source of disease Carriers through the combined use of probes and bio-markers, using a variety of preclinical imaging techniques. MR imaging has two advantages over other imaging techniques: higher spatial resolution (micrometer rather than several millimeters) and the fact that physiologic and anatomic information can be extracted simultaneously.

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